A Mini Review on Women’s Health, Focus on Menopause and Metabolic Challenges

Abstract

Women often play a central role in providing nutrition and care. The supportive character requires more attention to the concern of having a beautiful life. Health is central. In bustling cities to go to work, and the never-ending health routine kept her in check. In this paper, the short communication is to inform and gather evidence in support of women’s health and address their most frequent concerns over controlling the symptoms and managing their risks upon menopause. A woman’s strength is reflected in how she lives through health challenges. These issues highlight the fatigue and exhaustion caused by prolonged medication use and releasing herself from a worrisome condition to a severe one. Women tend to feel more liberated and health-conscious during this period when it comes to musculoskeletal and metabolic syndrome. Their daily routines of maintaining a healthy diet and engaging in physical exercise remain consistent.

Introduction

The pre-menopause stage is before having the actual event, due to maternal instincts and health concerns, such as dietary patterns and physical activities during their daily routine, to keep what is best for health in looking after others. The menstrual cycle ceased over the course of a year, influenced by medication use and vaginal dryness. Hormonal imbalances frequently result in mood fluctuations and emotional instability, especially under stress. The unnoticeable symptoms resulted in menopause or the experience of a heavy flow. Fibroid formation also occurs after the reproductive years. For instance, a condition called fibromyalgia occurs in the female reproductive system.

From suddenly feeling unwell in a previously calm state to the aggression of submersion as if there is a choke of unbreathable air. Then, she seeks medical advice for having an oxygen tank and nebulizer inhalation to have breathable air to clear her throat. There are also personalized calendars and journals to note the schedule before heading to the clinic. The atmosphere and the gaseous flow at room temperature make the situation even more anxious just by looking at the empty room with no one. They grabbed an elastic ball to have acupressure on the carpal area of the hands.

The pre-menopause is the early stage of detection of having the menstrual cycle stop after reproductive years [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The cessation of the menstrual cycle may be influenced by both genetic predispositions and broader health concerns. However, the series of chain events is of interest in following up with their well-being [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. Therefore, women in their 50s are eligible to know the signs and symptoms in preparing themselves for the body's maintenance and rejuvenation. Thus, there is a declaration on health awareness among women in ideal weight and bone structure. Their strong appearance is in a test for prevention measures and maintaining their younger-looking figure.

"Hence, the menopausal rating scale is used to assess symptoms on a scale from 1 to 10 [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The classification in body type, physical activity, health dos and don'ts, and waist circumference for blood circulation and physique characterization [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. Historical medical records also reported on their health profiles and food intakes to have it with the health condition [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The most prominent is the waist circumference and body weight increase due to a lack of exercise. Without realizing it, it requires body heat to regulate body temperature by having the right blood circulation.

Over time, bones and other bodily structures undergo degeneration, affecting their functionality, elasticity, and overall musculoskeletal integrity. The restructuring of the bone parts allows the cavity to support a muscle mass and bone mass when in motion, as the bendable limbs when walking [22Akbar A, Zaheer A, Kharal MM, Komel A, Khan MH, Ahsan A, Singh AK. Evolving strategies for osteoporosis management in postmenopausal women: From tradition to innovation. Medicine (Baltimore). 2025 Feb 14;104(7):e41605. doi: 10.1097/MD.0000000000041605. PMID: 39960896; PMCID: PMC11835067.]. Calcium and vitamin D are supplements for the growth and renewal of bone cells in the age of muscle expansion [22Akbar A, Zaheer A, Kharal MM, Komel A, Khan MH, Ahsan A, Singh AK. Evolving strategies for osteoporosis management in postmenopausal women: From tradition to innovation. Medicine (Baltimore). 2025 Feb 14;104(7):e41605. doi: 10.1097/MD.0000000000041605. PMID: 39960896; PMCID: PMC11835067.]. Hence, this study investigates endometrial thickening during menopause and explores its potential correlation with bacterial cell dynamics.

Scope of study

The intracellular and other metabolic activity in supporting a woman’s health may have more exposure and uneven concentration within the skin’s blood. The neurological disorders are yet to be found in a relentless and countless naming of new cells reformed to support wound healing and tissue repair over time. The pathogenic process is then being accumulated by the white blood cell counts to make it protective than ever. Extracellular cell defences may contribute to resisting various bodily invasions and nutrient uptake to be penetrated and react further within the body cells' composition. Thus, this mini-review focuses on the formation and interaction of various cell types and organs functioning system to be in a continuous process of living up to the fullest. It all starts from the root cause of the health concern, then follows a sequence of cellular and molecular structural changes, and finally, the end product is formed through a process of formation and an interactive field of multicellular decomposition of blood cells.

Etiology

The worrisome irregular cycles of menstruation took time to recover from, when the condition lasted for 12 months. The stress level and adrenaline are both in the same picture of causing more body anxiety. A mental health condition requires more relaxation time for the body to calm down and start over with the principle of strengthening and building musculoskeletal cells [33Perlman B, Kulak D, Goldsmith LT, Weiss G. The etiology of menopause: not just ovarian dysfunction but also a role for the central nervous system. Glob Reprod Health. 2018;3(2):e8.]. In return, the body is revitalized and re-energized. A menopausal transition is getting into the next stage, as there is a prior step to reverse back or take more precautionary ways in reforming and regenerating new cells to minimize the risk of muscle dystrophy and reduced bone density [33Perlman B, Kulak D, Goldsmith LT, Weiss G. The etiology of menopause: not just ovarian dysfunction but also a role for the central nervous system. Glob Reprod Health. 2018;3(2):e8.].

The most common inflammation is skin irritation with a burning sensation. Hormonal imbalances manifest with skin problems and other sudden changes in body development [33Perlman B, Kulak D, Goldsmith LT, Weiss G. The etiology of menopause: not just ovarian dysfunction but also a role for the central nervous system. Glob Reprod Health. 2018;3(2):e8.]. The severity of cases at a scatter dot point in a plot to show the sudden changes and body sensations with endocrinology fluctuations [33Perlman B, Kulak D, Goldsmith LT, Weiss G. The etiology of menopause: not just ovarian dysfunction but also a role for the central nervous system. Glob Reprod Health. 2018;3(2):e8.]. With endocrinology fluctuations, they face mood swings and spur at the moment for overreacting to situations [33Perlman B, Kulak D, Goldsmith LT, Weiss G. The etiology of menopause: not just ovarian dysfunction but also a role for the central nervous system. Glob Reprod Health. 2018;3(2):e8.]. Therefore, lack of exercise is presumed to be a weight gain resulting in a reduced estrogen level.

Women are in care throughout their lives as their health condition begins to be more detrimental and overtaken by the consequences of losing their functionality in metabolic activity [44Huang DR, Goodship A, Webber I, Alaa A, Sasco ER, Hayhoe B, El-Osta A. Experience and severity of menopause symptoms and effects on health-seeking behaviours: a cross-sectional online survey of community dwelling adults in the United Kingdom. BMC Womens Health. 2023 Jul 14;23(1):373. doi: 10.1186/s12905-023-02506-w. PMID: 37452317; PMCID: PMC10347781.]. In this alarming state, they are continuously being observed and followed up to address their concern over the longevity of their health and procurement from their suitability for a treatment. Regarding the bladder system, incontinence and water filtration are for further care by keeping the body hydrated throughout the process [44Huang DR, Goodship A, Webber I, Alaa A, Sasco ER, Hayhoe B, El-Osta A. Experience and severity of menopause symptoms and effects on health-seeking behaviours: a cross-sectional online survey of community dwelling adults in the United Kingdom. BMC Womens Health. 2023 Jul 14;23(1):373. doi: 10.1186/s12905-023-02506-w. PMID: 37452317; PMCID: PMC10347781.]. The symptoms are relieved with pharmacological and non-pharmacological approaches to practicing a healthy diet and increasing physical activity.

The principle is to replace the loss of body mechanisms when experiencing menopause. The first is menopause hormonal therapy in place of pills and gels to soothe the dryness and dysfunctionality of the incontinence and bleeding system [55Mukherjee A, Davis SR. Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions. Clin Endocrinol (Oxf). 2025 Jan 29. doi: 10.1111/cen.15211. Epub ahead of print. PMID: 39878309.]. The second is to alleviate the symptoms and other additional traumatic events when having the health condition. It reaches a calming effect after experiencing worries subside as health practitioners and nurses use different methods for the patient in a comfortable room and workspace.

Some minor adjustments in bone fractures have degraded the heart muscle and cardiovascular health [55Mukherjee A, Davis SR. Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions. Clin Endocrinol (Oxf). 2025 Jan 29. doi: 10.1111/cen.15211. Epub ahead of print. PMID: 39878309.]. Thus, unscheduled bleeding might increase anxiety levels to reduce and readjust heart-pumping activity at a normal pace [55Mukherjee A, Davis SR. Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions. Clin Endocrinol (Oxf). 2025 Jan 29. doi: 10.1111/cen.15211. Epub ahead of print. PMID: 39878309.]. The corpus luteum will also degenerate as the progesterone level drops. The need for what is lacking in the body, such as water hydration and energy metabolism, requires a healthy eating balance and practicing moderation when drinking water and other caffeinated drinks. Further, physical activity will improve circulation and ensure the body stays in shape. Remember, the body clock is always up for a circadian rhythm to be at a normal pace and consistent results (Table 1).

Table 1: Summary Table for Interaction and Pathways from the Outer Layer of Protection to the Inner Layers of Body Mechanism.

Pathophysiology

Primary amenorrhea is defined as if the menstrual cycle never even once, until she reaches 15 years old Nawaz, et al. 2024. The secondary one refers to the patient who has not undergone a menstrual cycle for 3 to less than 6 months for a normal state and 6 to more than 6 months for the abnormal ones Nawaz, et al. 2024. Healthcare professionals will attend and design a questionnaire consisting of the initial diagnosis and ways to manage menstruation during the evaluation. The self-proclamation of the need for examination may also require authorization in seeking future treatment, as the department is related.

Based on biological pathways, the process of urination and the lining is called the endometrium. The endometrium functions to allow blood flow and other excreted waste to be removed from the uterus. Other organs are yet to develop. The process could be restricted as the functionality and the maturing phase are caught between. For a different outcome and health adversity, medicated oil and pills may contribute to irregular and unstable conditions to resulting in an abnormal endometrial lining Nawaz, et al. 2024. The production level and hormonal changes started to imbalance the regulation process in different enzymatic body reactions over time.

For instance, follicle-stimulating hormone and luteinizing hormone are affected in the middle of ischemia, infection, or trauma Nawaz, et al. 2024. With the sudden changes in blood flow and pathogenic hormonal imbalances, there are several pathways for precautionary measures to control the overflowing and sudden fatigue in producing hormones to have a word with the body's metabolic function as the timekeeper. By experiencing more delay time, the patient might have also encountered gonadal disorders in experiencing hormonal changes. Notably, reproductive organ disorders may lead to altered nutrient uptake for the body. Then, a sudden development of a growth in body cells forms abnormal changes in the enlargement of organs Nawaz, et al. 2024. Body weight and composition were assessed using standardized measurement tools. It is about the fattiness and lack of muscular mass to support the whole body frame in a hospital, for other complications in terms of obesity and overweight.

Histology

As mentioned before, there are three sections for phases of menopause. The first one is perimenopause, the hormonal fluctuations that undergo the commencement of an uncontrollable number of body cells forming the enlargement of organs and glands called hyperplasia. The expansion of the body cells may have an adverb with internal fatness increases in size reported in the physical body measurement. The most prominent are waist enlargement and abdominal fat buildup in the stomach's lining.

Hormonal shifts may contribute to metabolic alterations, including weight loss. The residual changes resulted in a thickness of the endometrium with a lack of proliferation and mitotic activity. Cell proliferation occurs as a result of evolutionary processes during cell division, and the number of reproductive cells is determined by a selection process beyond the single cell's control [66Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021 Jan 8;45(1):fuaa046. doi: 10.1093/femsre/fuaa046. PMID: 32990752; PMCID: PMC7794046.]. Fortunately, bacterial cells remain viable for sustained division and population growth [66Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021 Jan 8;45(1):fuaa046. doi: 10.1093/femsre/fuaa046. PMID: 32990752; PMCID: PMC7794046.]. Bacterial populations demonstrate increased proliferation when exposed to optimal environmental conditions, suggesting a direct correlation between microbial growth dynamics and external factors [66Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021 Jan 8;45(1):fuaa046. doi: 10.1093/femsre/fuaa046. PMID: 32990752; PMCID: PMC7794046.]. After reaching a stabilized number of nucleoids, the Gram-positive and negative bacterial cells interacted in a polarized state of charges for enlargement and multiple cells to occur again [66Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021 Jan 8;45(1):fuaa046. doi: 10.1093/femsre/fuaa046. PMID: 32990752; PMCID: PMC7794046.].

The mitotic cycle finishes with the reproductive numbers of cells in another set of species in the body's growth and repair [66Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021 Jan 8;45(1):fuaa046. doi: 10.1093/femsre/fuaa046. PMID: 32990752; PMCID: PMC7794046.]. The final stage of postmenopause requires attention to the corpora albicanta. The corpora albicans consists of follicular and stromal cells for the development of an embryo during the birth process, to have it with the pregnancy status [77Kirkendoll SD, Bacha D. Histology, Corpus Albicans. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424854.]. The corpus luteum will shrink in size for the fetal cells to have a non-pregnancy status [77Kirkendoll SD, Bacha D. Histology, Corpus Albicans. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424854.]. Fibroblasts for the molecules of a stick-wax have on the atheroma lining for the clogging and blockage near the connective tissue [77Kirkendoll SD, Bacha D. Histology, Corpus Albicans. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424854.].

Therefore, a pharmacological approach to increasing progesterone allows the cells to be in both regrowth and repair states, for the cells to rejuvenate all over again [77Kirkendoll SD, Bacha D. Histology, Corpus Albicans. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424854.]. There is also a process called calcification that is left undetected even by the sonar machine, to have a medical examination for women's health status. The heart beating and pulse activity as the corpus luteum is about to shrink in size [77Kirkendoll SD, Bacha D. Histology, Corpus Albicans. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31424854.]. As noted in the literature, the size of the corpus luteum plays a crucial physiological role.

Histopathology

Thyroid disease has coexisted with menopause in women who have been through reproductive years [88Mintziori G, Veneti S, Poppe K, Goulis DG, Armeni E, Erel CT, Fistonić I, Hillard T, Hirschberg AL, Meczekalski B, Mendoza N, Mueck AO, Simoncini T, Stute P, van Dijken D, Rees M, Duntas L, Lambrinoudaki I. EMAS position statement: Thyroid disease and menopause. Maturitas. 2024 Jul;185:107991. doi: 10.1016/j.maturitas.2024.107991. Epub 2024 Apr 24. PMID: 38658290.]. Hypothyroidism states the outnumbered of thyroids in multicellular organisms by multiplying the numbers of metabolites for weight loss and hand trembling for the overstimulation of the extracellular cells in metabolic activity [88Mintziori G, Veneti S, Poppe K, Goulis DG, Armeni E, Erel CT, Fistonić I, Hillard T, Hirschberg AL, Meczekalski B, Mendoza N, Mueck AO, Simoncini T, Stute P, van Dijken D, Rees M, Duntas L, Lambrinoudaki I. EMAS position statement: Thyroid disease and menopause. Maturitas. 2024 Jul;185:107991. doi: 10.1016/j.maturitas.2024.107991. Epub 2024 Apr 24. PMID: 38658290.]. Perimenopause is not itself an illness but serves as a reminder of the bodily changes for adaptivity in different phases of life. Suboptimal findings show that the health condition gradually deteriorates as the condition worsens [88Mintziori G, Veneti S, Poppe K, Goulis DG, Armeni E, Erel CT, Fistonić I, Hillard T, Hirschberg AL, Meczekalski B, Mendoza N, Mueck AO, Simoncini T, Stute P, van Dijken D, Rees M, Duntas L, Lambrinoudaki I. EMAS position statement: Thyroid disease and menopause. Maturitas. 2024 Jul;185:107991. doi: 10.1016/j.maturitas.2024.107991. Epub 2024 Apr 24. PMID: 38658290.]. Tyrosine is also one of the metabolites. And hormonal secretions counterbalance the quantum of the body.

The pituitary gland in the endocrinology system, for a subarachnoid haemorrhage, releases hormonal reactions as a counter-reaction to lessen the bleeding. Thus, abnormal uterine bleeding is an iatrogenic health condition that raises the awareness of taking care of the bleeding and continuing to practice proper meals and physical activity daily to have effective results [99Davis E, Sparzak PB. Abnormal uterine bleeding. 2018.]. They are for the morbidities to heighten the level of bleeding due to fibroids. Excessive bleeding in the cavity is often linked to elevated fibrinogen levels, contributing to uncontrolled blood flow, to control internal bleeding. Then, it should be an invasive approach to surgical intervention [99Davis E, Sparzak PB. Abnormal uterine bleeding. 2018.].

In contrast to haemorrhagic conditions and irritable bowel syndrome, another possible symptom of the development of the health condition is abdominal pain due to bloating and bleeding of the intestines [99Davis E, Sparzak PB. Abnormal uterine bleeding. 2018.]. Coagulopathy and menopause are interchangeable in terms of having both combined, resulting in blood clots and heart disease [99Davis E, Sparzak PB. Abnormal uterine bleeding. 2018.]. Skin dehydration and nutrient deficiencies often result from hormonal imbalances, irregular blood circulation, and skin itchiness from pus [1010Kamp E, Ashraf M, Musbahi E, DeGiovanni C. Menopause, skin and common dermatoses. Part 2: skin disorders. Clin Exp Dermatol. 2022 Dec;47(12):2117-2122. doi: 10.1111/ced.15308. Epub 2022 Oct 26. PMID: 35727900; PMCID: PMC10092853.].

Epidemiology

From emotional imbalances to memory storage, women are more concerned about their health. Sweating experienced during menopause may be indicative of underlying physiological changes. Sometimes, they worked part-time jobs to support their family and catch up on their sleep. They should prioritize their health. There is also a statement saying that women face the odds of having depression over this matter [1111Fang Y, Liu F, Zhang X, Chen L, Liu Y, Yang L, Zheng X, Liu J, Li K, Li Z. Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis. BMC Public Health. 2024 Jul 2;24(1):1767. doi: 10.1186/s12889-024-19280-5. PMID: 38956480; PMCID: PMC11220992.]. However, it does not address the gap, and the findings are only confined to ethnicities and continents [1111Fang Y, Liu F, Zhang X, Chen L, Liu Y, Yang L, Zheng X, Liu J, Li K, Li Z. Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis. BMC Public Health. 2024 Jul 2;24(1):1767. doi: 10.1186/s12889-024-19280-5. PMID: 38956480; PMCID: PMC11220992.]. Paucity does not represent the whole population, as there is still a limitation of the study that remains uncertain in the face of the public.

Among the notable countries, there are main differences in body mass index and sleep problems [1111Fang Y, Liu F, Zhang X, Chen L, Liu Y, Yang L, Zheng X, Liu J, Li K, Li Z. Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis. BMC Public Health. 2024 Jul 2;24(1):1767. doi: 10.1186/s12889-024-19280-5. PMID: 38956480; PMCID: PMC11220992.]. Additionally, a correlation exists between depression and urinary tract problems [1111Fang Y, Liu F, Zhang X, Chen L, Liu Y, Yang L, Zheng X, Liu J, Li K, Li Z. Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis. BMC Public Health. 2024 Jul 2;24(1):1767. doi: 10.1186/s12889-024-19280-5. PMID: 38956480; PMCID: PMC11220992.]. Feelings of chest discomfort and restlessness frequently disrupt sleep during the night. Additionally, frequent urges to urinate and self-examination often lead to a sense of unease. Hence, they are the most common symptoms of sudden changes behind closed doors. Reports indicate that Chinese women report fewer issues related to sleep cycles and stress management [1212Yong Z, Yang Y, Yang Y, Yang L, Zhao Y, Luo X, Yan M, Zheng R. Prevalence and Severity of Menopausal Symptoms in Women of Different Ages - China, 2023-2024. China CDC Wkly. 2025 Mar 7;7(10):334-340. doi: 10.46234/ccdcw2025.054. PMID: 40225777; PMCID: PMC11982920.].

Therefore, the classification of menopause differs by ethnicity, educational level, and marital status [1212Yong Z, Yang Y, Yang Y, Yang L, Zhao Y, Luo X, Yan M, Zheng R. Prevalence and Severity of Menopausal Symptoms in Women of Different Ages - China, 2023-2024. China CDC Wkly. 2025 Mar 7;7(10):334-340. doi: 10.46234/ccdcw2025.054. PMID: 40225777; PMCID: PMC11982920.]. The age group has the most ranking and order according to stages of developing menopause [1212Yong Z, Yang Y, Yang Y, Yang L, Zhao Y, Luo X, Yan M, Zheng R. Prevalence and Severity of Menopausal Symptoms in Women of Different Ages - China, 2023-2024. China CDC Wkly. 2025 Mar 7;7(10):334-340. doi: 10.46234/ccdcw2025.054. PMID: 40225777; PMCID: PMC11982920.]. In Shanghai province, they have a better living standard that lessens their stress levels in different working occupations compared to Greece [1212Yong Z, Yang Y, Yang Y, Yang L, Zhao Y, Luo X, Yan M, Zheng R. Prevalence and Severity of Menopausal Symptoms in Women of Different Ages - China, 2023-2024. China CDC Wkly. 2025 Mar 7;7(10):334-340. doi: 10.46234/ccdcw2025.054. PMID: 40225777; PMCID: PMC11982920.]. Another condition is vasomotor syndrome [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. The medication is over-restricted due to accidental misuse and over dosage, to unnecessary health outcomes, and vice versa. Thus, a more thorough and clinically proven medical solution is for future relief and to reduce the symptoms of menopause. As the population grows, so do the healthcare settings due to the increased number of patients. It is not so much the numbers but the quality of life that they lived in.

Hypothesis reformulation for host-microbe interactions

The balanced combination of microbial secretions, supporting the human gut and its interrelationships with other microbiota, contributes to a well-regulated health system [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. The human gut is home to many microbes for the symbiotic relationships among the bacterial flora and other excretions of juices to have a good foundation and recipe for a high-quality and balanced diet in a proper meal [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. The bacterial component, which enhances into a double level of protection and the penetration inside the body requires a mass and energy for an electrolyte and microfluid balancing in optimizing the human digestion system [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. The metabolites undergo certain transformations into another metabolic activity of solidifying the molecules for better penetration and cross-section of their flow in the digestion, and aid in metabolites, called demineralization [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. As the tooth decays for the enamel forms a hardened texture of the strong foundation in fighting against germs and bacteria of the mouth, which ends up in well well-controlled environment to have the food being chewed, providing the smallest chunks of food into the digestive system [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. The calculation of microbiota formation across different domains as it seeps into the digestive and filtration systems may take time to develop. This process is not directly calculated but occurs in phases, which can be mathematically represented using a simple formula that accounts for flow dynamics and the concentration of liquefied substances [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.]. These pathways then evolve into different axes of interaction, in having arrows overshooting all over the place for their raging horsepower in taking care of the whole body [1414Jansma J, El Aidy S. Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021 Jan 20;9(1):16. doi: 10.1186/s40168-020-00955-1. PMID: 33472685; PMCID: PMC7819158.].

The viral assembly between proteins and virions is in a more intractable situation in a host pathogen for the process of breaking down into smaller molecules and a larger molecules in having it a cross sectional for more substances to be absorbed and released a different health components to have a supportive of immunity and digestive system [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.]. Host host-pathogen interaction is the interaction between the body and other metabolites, reactivity in silico to be available in the life span for the viruses and bacteria to have good or bad interactions to be digested along the way. In such a way, a cellular receptor is then the attachment and site binding for other naming relationships called multivalent adhesion molecules [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.]. Protein to protein and protein to lipid for the ultimate solution of dissolving the sub molecules and small particles, in another toxicity and other virulent penetration of several hosts involved in the penetration and substrate formation to allow transcription factors to activate and deactivate the cellular metabolism and gene expression for modelling the excessive cells in building a molecular pathways to have a final stage of a food substance in support for minerals and multivitamins [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.]. The multi-level of strains ensures the breaking down process of pathogens is in a well-conditioned and adverse containment for other adjusted life cycles. The continuous splicing and disintegration of biofumes and other toxic substances within the body ensure the body gets the most nourishment and replenishment in having new cells and other rejuvenated conditions to heal over time [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.].

Riboflavin and other interacting pathways contribute to a more adaptive environment, facilitating the binding of host-microbial cells at localized receptor and effector sites. This interaction influences both forward and reverse health conditions, supporting the development of new regenerative and rejuvenation processes for microbiota and symbiotic fluids. These advancements pave the way for meaningful medical interventions, strengthening the relationship between multicellular structures and organ transfer processes [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.]. Anti-oxidation and anti-inflammation for the body mechanism in having an interactive and biological pathways of becoming into another level of exposure and absorption to have in an electrolyte and other microfluid interchangeable site to have it in a name [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.]. Riboflavin for women’s health which more meaningful when it comes to reproduction and rebirth in terms of an infant’s health by giving the best nutrients and supplying the blood circulation in an even distribution for future exploration on microbiome cells. The more antifungal effects are taken into consideration for the cleansing and hygienic bio-composition of the blood cell counts to the skin reformation of overflowing with hormonal imbalances, then, turned into a beautiful harmony of a components to have it in a more related and uneven bases to flourish beneath the skin layers [1515Sen R, Nayak L, De RK. A review on host-pathogen interactions: classification and prediction. Eur J Clin Microbiol Infect Dis. 2016 Oct;35(10):1581-99. doi: 10.1007/s10096-016-2716-7. Epub 2016 Jul 29. PMID: 27470504.] (Figure 1).

Figure 1: The Metabolic and Logical Path findings in the Interwoven World of Microbiology.

Women's exposure to the working environment causes the shake and stir for more opportunities open in improve their health [1717Douthard R, Whitten LA, Clayton JA. Research on Women's Health: Ready for the Future. J Womens Health (Larchmt). 2022 Feb;31(2):133-144. doi: 10.1089/jwh.2022.0014. PMID: 35147467; PMCID: PMC8864416.]. The health integrity in delivering the best education system in introducing new health approaches by evaluated by the program of excellence proposed by the National Health Institute in the 1990s [1717Douthard R, Whitten LA, Clayton JA. Research on Women's Health: Ready for the Future. J Womens Health (Larchmt). 2022 Feb;31(2):133-144. doi: 10.1089/jwh.2022.0014. PMID: 35147467; PMCID: PMC8864416.]. It had risen on different occasions as the cardiovascular health and other circulatory problems engulfed under the scope of the medical field to have their immunity brazen by allowing more room for behavioral health to finally contribute to the relationship with vastness in the neurological problems [1717Douthard R, Whitten LA, Clayton JA. Research on Women's Health: Ready for the Future. J Womens Health (Larchmt). 2022 Feb;31(2):133-144. doi: 10.1089/jwh.2022.0014. PMID: 35147467; PMCID: PMC8864416.]. Women's provision of wellness for their well-being in giving back to the community for the outbreaks, including their hygienic care [1717Douthard R, Whitten LA, Clayton JA. Research on Women's Health: Ready for the Future. J Womens Health (Larchmt). 2022 Feb;31(2):133-144. doi: 10.1089/jwh.2022.0014. PMID: 35147467; PMCID: PMC8864416.]. They didn’t have to be afraid of handling them by themselves, but to put trust in the current issues and health systems implemented for their social welfare [1717Douthard R, Whitten LA, Clayton JA. Research on Women's Health: Ready for the Future. J Womens Health (Larchmt). 2022 Feb;31(2):133-144. doi: 10.1089/jwh.2022.0014. PMID: 35147467; PMCID: PMC8864416.]. The multidimensional health strategies implemented by the women’s health policy aim to have it cover all the major topics, from genetic to the molecular structure of hormonal imbalances and uneven circulation, to provide women with support over their concerns. Thus, social determinants explain more about the adjustable daily work and further enhance occupational safety hazards under a health condition.

The detrimental effects of menopausal transition on the vasomotor diagnoses of having a skin difference, hormonal imbalances, and sudden temporal emotional changes bring to the table for more alluring body mechanism [1818Opayemi, Oluwadamilola. (2025). Menopausal transition, uncertainty, and women’s identity construction: Understanding the influence of menopause talk with peers and healthcare providers. Communication Quarterly. 73. 1-25. 10.1080/01463373.2025.2466422.]. The need for support for health in the working environment is to have an ideal situation of educating themselves with the appropriate medical seeking treatment when being with their peers [1818Opayemi, Oluwadamilola. (2025). Menopausal transition, uncertainty, and women’s identity construction: Understanding the influence of menopause talk with peers and healthcare providers. Communication Quarterly. 73. 1-25. 10.1080/01463373.2025.2466422.]. Their pressure and stressful events have a milestone to their working progress and minute reviews put them in another phase of overcoming the obstacles with a firm supportive group. The underlying health problems bring out the behavioral causes and metabolism encompassing every moment of their busy schedule. Hormonal therapy took a major step in addressing the major step to regulate and balance the triggering factors of having an ideal metabolism to beat up the system in multicellular and fluid retention for water dehydration [1818Opayemi, Oluwadamilola. (2025). Menopausal transition, uncertainty, and women’s identity construction: Understanding the influence of menopause talk with peers and healthcare providers. Communication Quarterly. 73. 1-25. 10.1080/01463373.2025.2466422.]. The symptoms can be delivered verbally through a healthcare communication center, and given further instructions for strategizing for the biochemistry to upturn the flow of the circulatory system and the water balancing in an aquatic position for the prolonged term of their lives [1818Opayemi, Oluwadamilola. (2025). Menopausal transition, uncertainty, and women’s identity construction: Understanding the influence of menopause talk with peers and healthcare providers. Communication Quarterly. 73. 1-25. 10.1080/01463373.2025.2466422.]. The allocation of related resources to the medical materials in identifying the appropriate response to their healthcare management, overlooking the outsourcing for further enquiry [1818Opayemi, Oluwadamilola. (2025). Menopausal transition, uncertainty, and women’s identity construction: Understanding the influence of menopause talk with peers and healthcare providers. Communication Quarterly. 73. 1-25. 10.1080/01463373.2025.2466422.].

There are two stages of menopause, which are pre- and post, regarding the health empowerment of women. The earliest detection opens a new window for a more approachable one, overtaken by the publicized statements in addressing the health gap for even distribution of women’s health informatics in age [1919Sillence E, Osborne AK, Kemp E, McKellar K. Menopause apps: Personal health tracking, empowerment and epistemic injustice. Digit Health. 2025 Apr 27;11:20552076251330782. doi: 10.1177/20552076251330782. PMID: 40297381; PMCID: PMC12034958.]. Hormonal replacement therapy and cognitive behavioral therapy are in a relationship to have a definite piece of statistical modelling in overcoming the trends and gaps of uneven health distribution, such as the time of event to the onset of illness [1919Sillence E, Osborne AK, Kemp E, McKellar K. Menopause apps: Personal health tracking, empowerment and epistemic injustice. Digit Health. 2025 Apr 27;11:20552076251330782. doi: 10.1177/20552076251330782. PMID: 40297381; PMCID: PMC12034958.]. Menopause has a significant impact on the responses in feasibility of a model incorporated for futuristic movement in tracking visual representation of the biological pathways to the readership of the healthcare outputs [1919Sillence E, Osborne AK, Kemp E, McKellar K. Menopause apps: Personal health tracking, empowerment and epistemic injustice. Digit Health. 2025 Apr 27;11:20552076251330782. doi: 10.1177/20552076251330782. PMID: 40297381; PMCID: PMC12034958.]. Immune shift proliferation cells call in for more lymphocytes and interleukins in having the solidified and tracing more foreign antibodies in the world of antibiotics [1919Sillence E, Osborne AK, Kemp E, McKellar K. Menopause apps: Personal health tracking, empowerment and epistemic injustice. Digit Health. 2025 Apr 27;11:20552076251330782. doi: 10.1177/20552076251330782. PMID: 40297381; PMCID: PMC12034958.].

The gauge meters in menopause are hot flashes and night sweats, regulating in room temperature to have the cooling effect, and the condition itself is under control [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. Since the estrogen level is decreasing, the hormonal therapy then has an inoculation for antibodies enriched with the immune system to have an enhanced defense system at room temperature [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The bladder system experiences weakened pelvic floor and other muscles in conjunction with a health risk in the woman’s digestive and infiltration systems [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. Hence, the weight training and the subclavian fat in the abdominal area of a woman resulted in a subcutaneous fat [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The subcutaneous fat then develops into visceral fat as the fatty layer and the lining are in expand for more room of the glycerol and fatty acids for an energy store are affected as well [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.]. The blood circulation to the brain system is called the brain fog, for having trouble in restoring more memories and internal storage of healthy communication among the living [11Heavey P, Keegan P, Dunne N. Prevalence and severity of menopausal symptoms in peri and post-menopausal women. Ir Med J. 2025 Jan 27;118(1):2. PMID: 39998728.].

Further, premature menopause may affect their daily living lifestyle and sleeping behavior [2020Pant A, Gibson AA, Marschner S, Liao LP, Laranjo L, Chow CK, Zaman S. Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study. Heart. 2025 Feb 26;111(6):262-268. doi: 10.1136/heartjnl-2024-324602. PMID: 39689929; PMCID: PMC11874333.]. The sleeping pace is very convenient as the body circadian clock system goes on for the betterment of a woman’s health [2020Pant A, Gibson AA, Marschner S, Liao LP, Laranjo L, Chow CK, Zaman S. Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study. Heart. 2025 Feb 26;111(6):262-268. doi: 10.1136/heartjnl-2024-324602. PMID: 39689929; PMCID: PMC11874333.]. "However, there is no significant association between premature menopause and meat consumption, as dietary habits primarily influence metabolic activity. Hormonal dysregulation, rather than dietary choices, plays a larger role in affecting blood flow and addressing inconsistencies in circulation [2020Pant A, Gibson AA, Marschner S, Liao LP, Laranjo L, Chow CK, Zaman S. Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study. Heart. 2025 Feb 26;111(6):262-268. doi: 10.1136/heartjnl-2024-324602. PMID: 39689929; PMCID: PMC11874333.]. Hormonal changes due to spicy food and caffeinated drinks may enhance the uncontrollable and have the bounce off effect against the wall in the uterus wall for more affirmative reasons in creating a new ideal environment for women to live in [2020Pant A, Gibson AA, Marschner S, Liao LP, Laranjo L, Chow CK, Zaman S. Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study. Heart. 2025 Feb 26;111(6):262-268. doi: 10.1136/heartjnl-2024-324602. PMID: 39689929; PMCID: PMC11874333.]. Based on astounded and figures in adding more valuable information to the field of women’s health, the disparities are often compared to the degree of statistical differences in acknowledging their differences in the time that they spare [2020Pant A, Gibson AA, Marschner S, Liao LP, Laranjo L, Chow CK, Zaman S. Age of menopause, healthy lifestyle and cardiovascular disease in women: a prospective cohort study. Heart. 2025 Feb 26;111(6):262-268. doi: 10.1136/heartjnl-2024-324602. PMID: 39689929; PMCID: PMC11874333.].

The skin elasticity disembodies the pigmentation and protective barrier when it comes to prolonged UV exposure the nourished by minerals, which are crystallized as salt and water to form electrolytes of having byproducts to maintain the body fluidity [2121Merzel Šabović EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024 Jun;30(2):85-94. doi: 10.1177/20533691241233440. Epub 2024 Feb 20. PMID: 38379168.]. The arterial stiffness leads to a high chance of developing a manifested cardiovascular disease predisposed to uncontrollable blood circulation during menopause [2121Merzel Šabović EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024 Jun;30(2):85-94. doi: 10.1177/20533691241233440. Epub 2024 Feb 20. PMID: 38379168.]. The biosynthesis of estrogen supports a protective skin barrier while aiding elastin in dilating and relaxing blood flow in response to pressure, which is regulated by external environmental factors [2121Merzel Šabović EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024 Jun;30(2):85-94. doi: 10.1177/20533691241233440. Epub 2024 Feb 20. PMID: 38379168.]. The cellular aging increases the oxidative stress to the metabolic activity as the food and excretion mechanisms are controlled by the triggering factor of an imbalanced power intake [2121Merzel Šabović EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024 Jun;30(2):85-94. doi: 10.1177/20533691241233440. Epub 2024 Feb 20. PMID: 38379168.]. Thus, nitric oxide has an added value to the alternative therapy for a better look at air constriction and elasticity of the arterial walls when facing another blood pressure [2121Merzel Šabović EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024 Jun;30(2):85-94. doi: 10.1177/20533691241233440. Epub 2024 Feb 20. PMID: 38379168.].

The changes in muscle mass and bone density for the cross section of having a decay in reduced estrogen levels [2222Pinheiro VDS, Proctor DN, Nogueira Soares R, Alvares TS. Effect of 12-wk dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females. Am J Physiol Heart Circ Physiol. 2025 Apr 1;328(4):H937-H944. doi: 10.1152/ajpheart.00065.2025. Epub 2025 Mar 11. PMID: 40066813.]. Systemic circulation is then overflown by the biosynthesis in having a molecular interaction for more well-being among the healthy subjects [2222Pinheiro VDS, Proctor DN, Nogueira Soares R, Alvares TS. Effect of 12-wk dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females. Am J Physiol Heart Circ Physiol. 2025 Apr 1;328(4):H937-H944. doi: 10.1152/ajpheart.00065.2025. Epub 2025 Mar 11. PMID: 40066813.]. In a biochemical of supporting the world of breathing difficulties, they have to add more oxygen supply and improve their air flow rate by drinking more fluids and breathing in air humidifiers that filter out the dust and other harmful fumes [2222Pinheiro VDS, Proctor DN, Nogueira Soares R, Alvares TS. Effect of 12-wk dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females. Am J Physiol Heart Circ Physiol. 2025 Apr 1;328(4):H937-H944. doi: 10.1152/ajpheart.00065.2025. Epub 2025 Mar 11. PMID: 40066813.]. The pressure in ventilation causes chest tightness as the skin further develops into different pigmentation and other skin disorders [2323Baldursdottir S, Gunnarsdottir K, Donaldsson S, Jonsson B, Drevhammar T. Skin-to-skin stabilisation and uninterrupted respiratory support for preterm infants after birth: feasibility of a new and simplified rPAP system. Arch Dis Child Fetal Neonatal Ed. 2024 Oct 18;109(6):638-642. doi: 10.1136/archdischild-2023-326409. PMID: 38514168; PMCID: PMC11503089.]. The neonatal intensive care to have emergency treatment among the patients is crucial for the oxygen mask and other breathing facilities intact with the outer skin layer [2323Baldursdottir S, Gunnarsdottir K, Donaldsson S, Jonsson B, Drevhammar T. Skin-to-skin stabilisation and uninterrupted respiratory support for preterm infants after birth: feasibility of a new and simplified rPAP system. Arch Dis Child Fetal Neonatal Ed. 2024 Oct 18;109(6):638-642. doi: 10.1136/archdischild-2023-326409. PMID: 38514168; PMCID: PMC11503089.]. The gas chamber and catheterization are two unrelated terms for representing membrane oxygen and carbon dioxide discharge enough particles to have a fast and recovered muscular and breathable situation [2323Baldursdottir S, Gunnarsdottir K, Donaldsson S, Jonsson B, Drevhammar T. Skin-to-skin stabilisation and uninterrupted respiratory support for preterm infants after birth: feasibility of a new and simplified rPAP system. Arch Dis Child Fetal Neonatal Ed. 2024 Oct 18;109(6):638-642. doi: 10.1136/archdischild-2023-326409. PMID: 38514168; PMCID: PMC11503089.].

The psychological well-being and the update on their social interaction are in for another chapter in their lives [2424Cucinella L, Tiranini L, Nappi RE. Impact of climate and environmental change on the menopause. Maturitas. 2023 Dec;178:107825. doi: 10.1016/j.maturitas.2023.107825. Epub 2023 Aug 25. PMID: 37634295.]. Their meditation are put on hold for more excessive food intake and other problematic behaviors in a very hectic population of study [2424Cucinella L, Tiranini L, Nappi RE. Impact of climate and environmental change on the menopause. Maturitas. 2023 Dec;178:107825. doi: 10.1016/j.maturitas.2023.107825. Epub 2023 Aug 25. PMID: 37634295.]. Thus, their well-being ended up in a wide coverage of the populated world of human health subjects by then, developed and more curable, as there are more diverse naturopathy and herbal medicinal practices for the menopause [2424Cucinella L, Tiranini L, Nappi RE. Impact of climate and environmental change on the menopause. Maturitas. 2023 Dec;178:107825. doi: 10.1016/j.maturitas.2023.107825. Epub 2023 Aug 25. PMID: 37634295.]. The red pine bark, on the other hand, has a property of pycnogenol to alleviate the symptoms of menopause in sight, for more herbal essences, and the impurities are removed to ensure the toxicity, and the water is purified for further electrolytes and sufficient fluid intake to avoid further dehydration [2525Lee HW, Choi TY, Lee MS, Lee JA, Jun JH, Choi J, Ang L, Lee CH, Lee JM, Park KS, Kim DC, Jang SR, Yoo JE, Kim DI, Cho SH, Yang SJ, Lee IS, Ahn IS, Lee DN, Choi CM, Song MH, Kim E. Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: a multicenter retrospective study. Integr Med Res. 2021 Sep;10(3):100706. doi: 10.1016/j.imr.2020.100706. Epub 2020 Dec 4. PMID: 33665094; PMCID: PMC7903342.]. The red ginseng is more suitable for middle-aged women facing different phases in their lives of overcoming unstable health conditions, the stressful traumatic events, to name a few [2525Lee HW, Choi TY, Lee MS, Lee JA, Jun JH, Choi J, Ang L, Lee CH, Lee JM, Park KS, Kim DC, Jang SR, Yoo JE, Kim DI, Cho SH, Yang SJ, Lee IS, Ahn IS, Lee DN, Choi CM, Song MH, Kim E. Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: a multicenter retrospective study. Integr Med Res. 2021 Sep;10(3):100706. doi: 10.1016/j.imr.2020.100706. Epub 2020 Dec 4. PMID: 33665094; PMCID: PMC7903342.]. The health informatics is then developed into a more adaptive networking system to introduce the new health line care products despite their necessity in a woman’s life [2525Lee HW, Choi TY, Lee MS, Lee JA, Jun JH, Choi J, Ang L, Lee CH, Lee JM, Park KS, Kim DC, Jang SR, Yoo JE, Kim DI, Cho SH, Yang SJ, Lee IS, Ahn IS, Lee DN, Choi CM, Song MH, Kim E. Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: a multicenter retrospective study. Integr Med Res. 2021 Sep;10(3):100706. doi: 10.1016/j.imr.2020.100706. Epub 2020 Dec 4. PMID: 33665094; PMCID: PMC7903342.].

Limitations of the study

Several factors are involved in a woman's health. For instance, the availability of the data is insufficient due to the underrepresentation of women's decree of confidentiality in assessing their different health characteristics and profiles in addressing certain health problems. Besides having the knowledge to abstain from their health condition, they rely on certain health referees to further validate their instincts and other promising results from a clinical study. Hence, the reliability of the result is not relevant and is still under a research study to obtain a representative and more generalized case of studies. Thus, not every health subject in the selection and eligibility criteria has the precision in medical diagnosis and treatment strategies.

Their prior beliefs are conditioned on the outcomes side to side without further involving a moderating effect in putting a more weighted scale to have an imbalanced proportion in coming out with further solutions to handle the hidden or latent variables to create a more viable model. The influence of spurious variables remains statistically unsubstantiated. The robustness depends on the sample size and the statistical power of a parameter for the variability of health subjects in the data dispersion. The omission variables are removed based on the bias of the estimate.

A woman's feelings change at the spur of the moment. It is not detectable at the moment of the cross-sectional study. At baseline, the medication or stress level is dysregulated and elevated uncontrollably due to hormonal fluctuations while experiencing changes in skin health. Their working fields require them to be independent and seek more traveling time for self-treatment and skin rejuvenation. However, the instantaneous result is only temporary as the everlasting caring lasts on their permanent change in a healthy routine. Their sleep cycles are on the inner and outer edges of their sleep deprivation. Frequent yawning may result in puffiness around the eyes. To reduce sleepiness, they managed to treat it with more breathable oxygen in the breathing system and reduce eye strain while using a laptop.

Future directions

In the hope of something more, women are there for their skin complexions. They are more confident in handling them as their age does not resemble their looks, for their true beauty. Viewing life through a reflective lens empowers women and amplifies their voices. The spirit of their life dimension is focusing and trusting in themselves to reach the consciousness of health, bickering. The exchanging of words and wisdom makes them who they want to be, as needed for their words of encouragement. As mentioned before, their motivation is to become the researcher of their own. They continue to seek knowledge, addressing the persistent gaps in women's health research. Then, an optimal balance in the age gap for the quantum of health in the age of artificial intelligence. The differences are widening as more people are into study for more to come in addressing their rights in health confidentiality.

From over-the-counter medication to behavioural therapy in assessing a woman’s mind to have a glance at their overall health [2626Simon JA, Davis SR, Lindén Hirschberg A, Kiesel L, Pompei LM, Reginster JY, Simoncini T, Hillard T. State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. Climacteric. 2025 Apr;28(2):98-103. doi: 10.1080/13697137.2025.2457993. Epub 2025 Feb 10. PMID: 39928407.]. The mood is under a memory and sleeping wellness division to have the data abundance in predicting the clock hours of managing the symptoms more productively [2626Simon JA, Davis SR, Lindén Hirschberg A, Kiesel L, Pompei LM, Reginster JY, Simoncini T, Hillard T. State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. Climacteric. 2025 Apr;28(2):98-103. doi: 10.1080/13697137.2025.2457993. Epub 2025 Feb 10. PMID: 39928407.]. Thus, troubleshooting the menopause issue will assist them in getting enough information to be further analysed within the range of the population study [2626Simon JA, Davis SR, Lindén Hirschberg A, Kiesel L, Pompei LM, Reginster JY, Simoncini T, Hillard T. State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. Climacteric. 2025 Apr;28(2):98-103. doi: 10.1080/13697137.2025.2457993. Epub 2025 Feb 10. PMID: 39928407.]. The new approach of having a more reliable and related life scenario to their everyday lives is crucial for their health management [2727Ahmed SB, Hardcastle L. Menopause: Time for a Paradigm Shift. Mayo Clin Proc. 2023 Jun;98(6):818-820. doi: 10.1016/j.mayocp.2023.04.014. PMID: 37270266.]. Based on the well-informed decision-making, the viability of a quantitative model to be implemented in a life decision-making process to educate women on their health is entrusted among their social backgrounds [2727Ahmed SB, Hardcastle L. Menopause: Time for a Paradigm Shift. Mayo Clin Proc. 2023 Jun;98(6):818-820. doi: 10.1016/j.mayocp.2023.04.014. PMID: 37270266.].

These dramatic changes have been effectively addressed to ensure an immediate healthcare response to their health care needs in time [2828Lega IC, Fine A, Antoniades ML, Jacobson M. A pragmatic approach to the management of menopause. CMAJ. 2023 May 15;195(19):E677-E672. doi: 10.1503/cmaj.221438. PMID: 37188372; PMCID: PMC10185362.]. The median intervals for follicle-stimulating hormone are then revised and remodeled for a life transition to undergo some changes in their lifestyles for more modified and changes in their dietary intake and physical exercise [2828Lega IC, Fine A, Antoniades ML, Jacobson M. A pragmatic approach to the management of menopause. CMAJ. 2023 May 15;195(19):E677-E672. doi: 10.1503/cmaj.221438. PMID: 37188372; PMCID: PMC10185362.]. The neurological and skeletal system also may assist in improving their biocharacteristics and metabolites in supercharging the particles into the world of pharmacology [2828Lega IC, Fine A, Antoniades ML, Jacobson M. A pragmatic approach to the management of menopause. CMAJ. 2023 May 15;195(19):E677-E672. doi: 10.1503/cmaj.221438. PMID: 37188372; PMCID: PMC10185362.]. In a menopause status, their modular changes to the hormonal changes in emotional sudden breakthroughs to enhanced with the ecological system of recurrence in studying their modality effects in time [2929Hosseinpour Z, Rezaei-Tavirani M, Akbari ME. Bioinformatic Identification of Hub Genes Related to Menopause-Obesity Paradox in Breast Cancer. Int J Endocrinol Metab. 2023 Nov 6;21(4):e140835. doi: 10.5812/ijem-140835. PMID: 38666041; PMCID: PMC11041819.]. Hormonal balances and premature ovarian failure could be a stage for seeking more life adjustments and behavioural control over the stressful event and how to handle further enquiries on the health condition [2929Hosseinpour Z, Rezaei-Tavirani M, Akbari ME. Bioinformatic Identification of Hub Genes Related to Menopause-Obesity Paradox in Breast Cancer. Int J Endocrinol Metab. 2023 Nov 6;21(4):e140835. doi: 10.5812/ijem-140835. PMID: 38666041; PMCID: PMC11041819.].

The sulfates and androgens are intact for more inhibition in the proposed area of working mechanisms and protection in a cytokinesis variability of a protoplasm [3030Nieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A. Menopausal shift on women’s health and microbial niches. NPJ Womens Health. 2025;3(1):3.]. However, the protoplasm has an indirect effect within the living cells of division [3030Nieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A. Menopausal shift on women’s health and microbial niches. NPJ Womens Health. 2025;3(1):3.]. Prohylaxis in the name of a medical pronounce of removing wastes and taking in nutrients and minerals for more energetic and kinetic purposes, the dynamic effect of disembowelment [3030Nieto MR, Rus MJ, Areal-Quecuty V, Lubián-López DM, Simon-Soro A. Menopausal shift on women’s health and microbial niches. NPJ Womens Health. 2025;3(1):3.]. The bone metabolism is then undergone for more health changes in hormonal balances to have the uptake more than just an intake [3131Mavaddat N, Frost D, Zhao E, Barnes DR, Ahmed M, Barwell J, Brady AF, Brennan P, Conti H, Cook J, Copeland H, Davidson R, Donaldson A, Douglas E, Gallagher D, Hart R, Izatt L, Kemp Z, Lalloo F, Miedzybrodzka Z, Morrison PJ, Murray JE, Murray A, Musgrave H, Searle C, Side L, Snape K, Tripathi V, Walker L, Archer S, Evans DG, Tischkowitz M, Antoniou AC, Easton DF. Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: Results from EMBRACE. medRxiv. 2025 Feb.]. Hormonal therapy is in place for more invasive and less painful medication for the post menopausal condition of an early age [3131Mavaddat N, Frost D, Zhao E, Barnes DR, Ahmed M, Barwell J, Brady AF, Brennan P, Conti H, Cook J, Copeland H, Davidson R, Donaldson A, Douglas E, Gallagher D, Hart R, Izatt L, Kemp Z, Lalloo F, Miedzybrodzka Z, Morrison PJ, Murray JE, Murray A, Musgrave H, Searle C, Side L, Snape K, Tripathi V, Walker L, Archer S, Evans DG, Tischkowitz M, Antoniou AC, Easton DF. Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: Results from EMBRACE. medRxiv. 2025 Feb.].

The time duration of exposure to the alignment for the more habitual and localised site of having a different biological pathway of metabolic and regenerative processes in the time space for having a more harmonious body mechanism undergoing some changes to a woman [3232Kızıltaş Ö, Fidancı İ. Assessment of duration of menopause and risk of cardiovascular events in postmenopausal women. Cukurova Med J. 2025;50(1):181–7.]. The body clock and automated system in circulating and reversing the predisposed orders of further ambiguity in a medical referential statement [3232Kızıltaş Ö, Fidancı İ. Assessment of duration of menopause and risk of cardiovascular events in postmenopausal women. Cukurova Med J. 2025;50(1):181–7.]. The woman’s hand grip of feeling the pressure and the extensive muscle stretch to ensure the blood pressure and oxygenation are in place for more breathable air [3333Freitas JPC, Santos JNV, de Moraes DB, Gonçalves GT, Teixeira LADC, Otoni Figueiró MT, Cunha T, da Silva Lage VK, Danielewicz AL, Figueiredo PHS, Costa HS, Sartorio A, Silva TJ, da Silva Júnior FA, Fonseca CA, Esteves EA, Lacerda ACR, Mendonça VA. Handgrip strength and menopause are associated with cardiovascular risk in women with obesity: a cross-sectional study. BMC Womens Health. 2025 Apr 4;25(1):157. doi: 10.1186/s12905-025-03702-6. PMID: 40186225; PMCID: PMC11969924.]. The physical assessment might also be a challenge in handling the grip more firmly in executing the muscle strength along the posture to have the exact body movement in meeting with further specification of the body’s physical strength [3333Freitas JPC, Santos JNV, de Moraes DB, Gonçalves GT, Teixeira LADC, Otoni Figueiró MT, Cunha T, da Silva Lage VK, Danielewicz AL, Figueiredo PHS, Costa HS, Sartorio A, Silva TJ, da Silva Júnior FA, Fonseca CA, Esteves EA, Lacerda ACR, Mendonça VA. Handgrip strength and menopause are associated with cardiovascular risk in women with obesity: a cross-sectional study. BMC Womens Health. 2025 Apr 4;25(1):157. doi: 10.1186/s12905-025-03702-6. PMID: 40186225; PMCID: PMC11969924.].

By incorporating demographic characteristics and further engulfment of information, prohibiting them from making any further omissions and spurious regression to the endless pursuit of gaining more health educators to define menopause [3434Hajesmaeel-Gohari S, Shafiei E, Ghasemi F, Bahaadinbeigy K. A study on women's health information needs in menopausal age. BMC Womens Health. 2021 Dec 28;21(1):434. doi: 10.1186/s12905-021-01582-0. PMID: 34961491; PMCID: PMC8712206.]. The spendless night of a primitive to accumulate the whole story on hold for another chapter in their lives. The mind is sharpened by their broad outlook for seeking more knowledge in what becomes of a life expectancy more meaningful in terms of their birth and living processes in a cyclical process of life improvement [3535Sharp CA, Dennis N, Hobson G, Hamilton-Kirkwood M, Hughes K. Where Are the Knowledge Gaps in Menopause Across a Population? A National Cross-Sectional Survey in Wales. Int J Environ Res Public Health. 2025 Feb 14;22(2):287. doi: 10.3390/ijerph22020287. PMID: 40003512; PMCID: PMC11855723.].

Key findings

1. The skeletal system is more than just a support of movement, but also adjustable to the changes in the environment by exercising more to avoid any lack of bone density.
2. The lack of permeable pathways in overcreating possible ways of communicating with other microbial cells has deactivated the functional cells in another outlook for body penetration.
3. There is a need for possible solutions when overcoming and facing the body challenges in making the best optimisation in having a more protective barrier on site.
4. The final outcome should maintain a practical and health-conscious balance to ensure the overall well-being is taken care of.
5. The power balancing of creating an energy output for future intakes in being more immune and adaptive to the new working and housing development.

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Ibrahim NAB. A Mini Review on Women’s Health, Focus on Menopause and Metabolic Challenges. IgMin Res. May 08, 2025; 3(5): 217-225. IgMin ID: igmin302; DOI:10.61927/igmin302; Available at: igmin.link/p302

• DOI10.61927/igmin302

08 Mar, 2025

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07 May, 2025

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Womens Health and Care