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Biography
Dr. Yukio Kimata is an Associate Professor in the Division of Biological Science at the Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Japan. Located in Ikoma, Nara Prefecture, NAIST is renowned for its interdisciplinary research in biological, information, and material sciences .
Dr. Kimata's research focuses on cellular responses to stress, particularly the unfolded protein response (UPR) in eukaryotic cells. His work utilizes the yeast Saccharomyces cerevisiae as a model organism to study how cells manage protein misfolding and maintain cellular homeostasis. Notably, his research has explored the artificial activation of the UPR to enhance the endoplasmic reticulum's capacity for protein processing.
In addition to his academic role, Dr. Kimata has contributed to various scientific publications and has been recognized for his work in the field of molecular biology and biotechnology. His affiliations include the Ohsumi Frontier Science Foundation, where he is a Yeast Consortium Fellow.
For more information or to contact Dr. Kimata, you can visit his laboratory's official page at NAIST.
Research Interest
Dr. Yukio Kimata's research focuses on cellular stress responses, particularly the unfolded protein response (UPR) in eukaryotic cells. He investigates how cells detect and manage misfolded proteins within the endoplasmic reticulum (ER) to maintain cellular homeostasis. Using the model organism Saccharomyces cerevisiae, Dr. Kimata explores the molecular mechanisms behind UPR activation, aiming to understand how cells balance protein folding and degradation processes under stress conditions. His work also includes exploring strategies to artificially enhance UPR activation to improve the capacity of the ER for protein processing. This research has significant implications for understanding diseases related to protein misfolding, such as neurodegenerative diseases, and for advancing biotechnology applications involving protein production. Additionally, Dr. Kimata’s studies contribute to broader fields like molecular biology, cell biology, and biotechnology, with a particular emphasis on protein quality control systems.
Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.
Upon dysfunction of the Endoplasmic Reticulum (ER), eukaryotic cells provoke a gene expression program, namely, the Unfolded Protein Response (UPR), leading to an increase in the size and function of the ER. In the yeast Saccharomyces cerevisiae, the UPR is modulated by the Hac1i protein, which is a transcription factor produced by ER stress. When the UPR is artificially triggered under non-stress conditions by artificial expression of the Hac1i protein, S. cerevisiae cells carry an enforced and enlarged ER, which allows us to obtain commercial...ly valuable materials such as secretory proteins and functional lipids abundantly.
Division of Biological Science, Department of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
0000-0002-0942-5385 
